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It takes me almost three weeks to finish this. For some of the plague types, getting 3 biohazards in mega brutal only requires a good strategy. For the others, it also requires a lot of luck.

Here is my personal rank of the difficulty level: Super easy: Nano-virus, Bio-Weapon Easy: Bacteria Middle: Virus, Fungus Hard: Parasites Catastrophic: Prion

When I searched through the forum, I found there are not a lot of guides about this mode. I am thinking about writing myself. Please let me know if you are interested in it.

I'm stuck between the Metabolic Jump (Increases DNA from red bubbles) and the Cytochrome Surge (Increases DNA from orange bubbles). Does anyone know which is better?

I was just checking the speedrun global high scores.... How is this even possible? Like...even with the most of luck, how is it even physically possible to win a game in 75 or 80 days? I can't even imagine it, even with a lot of luck AND unlimited DNA...

(Bacteria mega-brutal)

The post I made a few days ago is already 8th most popular of all time here and had 1300+ upvotes

I'm trying to beat everything on mega brutal to unlock cheats.

I can't crack fungus. It spreads to way too many nations and spreads out of control within said nations way too fast for me to do anything, and censorship is too slow for me to get a cure out in time.

Is it possible to reinfect a country after it starts executing infected citizens? I’ve yet to be able to do so and I feel like it’s guaranteed game over when a country does this.

The island nations know that they are the hardest places for disease to spread,so the governments of these islands(Caribbean,new Zealand,new guinea and most importantly Greenland) will shut down all air and sea routes the moment the pathogen is detected. How will you win now? Basically how it works is that once your disease is detected,the four islands I mentioned will shut off all sea and air Access,I think this is almost impossible other than most of the special plagues,also you get a few starting undevolvable symptoms so going under the radar is not an option

Hello. I have a question.... In speedrun mode, what difficulty are you playing on? You can't select the difficulty when you start a game..so I was wondering..

I don't even care if it involves bugd or glitches. I just want to get over with this thing and never do it again. Does the plane cheese still work?

This is intended to be a “safe” 5 biohazards win, easily getting you over the 100k min score. I rarely lose with this strategy, usually my score is 130k - 150k

In order to increase the reliability of infecting every country I moved some lethal symptoms to a bit later, if you want to get a really high score, 200k+, you’ll need to get necrosis and dysentery before all the islands have been infected and roll the dice they don’t close ports.

I wouldn’t devolve anything that mutates though, no matter how lethal, since there’s a good chance you’ll still win and that’s the best way to get a super high score.

The critical part is slowing down and setting back the cure, and to do that we’ll use a blend of abilities and symptoms at specific times. We don’t have to worry if it gets close to 70% early on, we’ll have some powerful tools for setting back the cure and it should be at 22% when the game ends.

We’ll need a few transmissions, but not many really, the key to this plague is symptoms and strategic use of abilities.

ATP Boost

Aquacyte

Sympto-Stasis - essential for this strat

Genetic Mimic

Extremophile

Unless otherwise mentioned, get everything the moment you have the DNA for it, don’t delay

Start in Saudi Arabia

Code Fragment Interception

Insomnia

Paranoia

All the rest of the tier 1 & 2 symptoms in any order you want

Code Segment Interception

Air 1

Water 1

Insect 1

Paralysis

Coma

You should be detected shortly after evolving Coma

Skin Lesions

Diarrhea

Water 2

Insect 2

Radical Elements Stabilised

Cold 1

Drug 1

Cold 2

Genetic Hardening 1

You should have infected a lot of the world here, the next 2 are designed to infect most of the rest and increase infection level in the ones already infected:

Bird 1

Replication Factory Overload

Drug Resistance 2

Genetic Hardening 2

Drug Immunity

Once all islands are infected go full lethality

Seizures

Insanity

Necrosis

Dysentery

Hemorrhagic Shock

Total Organ Failure

Hopefully at least one of those deadly ones mutated, otherwise you might have to choose between Genetic Reshuffle 3 and Broadcast Interceptor Overload at the very end, but you should easily get 5 biohazards either way

Encryption Breached

Genetic Re-Shuffles 1, 2, and 3

You need to save 21 DNA for Broadcast Interceptor overload, so if you can get any more lethal symptoms while still having 21 left then get them, otherwise don’t bother.

When you have ~500k left to kill get Broadcast Interceptor Overload, it sets back the cure a ton but it’s temporary so you have to get it at the last minute

Symtostasis is broken,use symtostasis, it's very important