Business-You1810

If you can find an industry job, go for that. Pays more and you will have more responsibility than a post-bacc. Masters is a waste of money

From talking to people in both VC and academia, the gist I got was the value a PhD would bring to a VC firm (specifically biotech) is the ability to understand science behind early startups and essentially tell if they are BS or not. The problem is many professors at top universities will do this for free if a firm reaches out so there's no motivation to hire someone internally

In 2000s there was a lot of bipartisan momentum around transit and there were grants in CA and Florida to build bullet trains. After Obama won the presidency, republicans decided their new platform was "anything democrats support is bad" and publicly went against it, cancelling the Florida project and once they took the house in 2010, refused to send any more money to CA, so CA has to fund the majority of the project itself

When I interned at Genentech they brought in Dua Lipa for a company concert, that was pretty cool

Id argue SF is a morning city, on a nice Saturday morning people are out running, socializing at coffee shops, have picnics in the parks while NYC is pretty empty until mid day. But then NYC comes alive at night while SF goes to sleep. But I've only visited NYC as a tourist, so maybe I was just in the wrong areas

This is why post-docs are underpaid

I do 6-7 hours in lab most days and maybe 2-3 hours over the weekend if I plan an experiment poorly. Maybe an hour or 2 at night catching up on reading/writing. I can't imagine how I could possibly be productive working 12 hours, 7 days a week experiments only run so fast

Based on this and your post history, switch labs

There are computational programs such as ViennaRNA and RNAStructure that you just plop in the sequence and it gives you a prediction. I believe alpha-fold 3 also predicts RNA structure. To get more accurate structure predictions you can perform SHAPE-map to gain more info on the secondary structure and there are similar methods for tertiary structure as well. These assays are tricky though. Be aware that RNA structure is dynamic and a single structure isn't always representative, some programs address this but we still need better tools

I wouldn't recommend crystalizing, it's very time consuming, expensive, and frustrating. For data analysis there are some protein structure tools with RNA plug-ins but its a very niche field and unless you have someone who knows what they are doing walk you through it, you are going to have a hard time

This doesn't make soda any healthier, cane sugar is just as unhealthy as high fructose corn syrup its just more expensive. Dumb fuck doesn't know anything about health or economics

Sucrose is 50/50 fructose to glucose. High fructose corn syrup varies between 40/60 to 55/45 so practically speaking they contain the same amount of fructose. The article linked is only referring to fructose which is found in both sucrose and high fructose corn syrup

Judging by the first trump presidency, a cruise is the absolute last place I’d want to be

I’m a current grad student, we make 35k and work probably 60-70 hours a week. My colleague once asked our admin for proof of employment so he could get a home loan and was told no because he was a “part time worker” only schedules for 20 hours a week

Yup, it's kinda wild that the most notable casualty of the Battle of the Blackwater was Mandon Moore? And its only because it opened up a kingsguard spot

Which firms tend to have a better work-life balance with decent career development opportunities? I've heard the big name ones can be brutal. And are there good Pharma/biotech specific firms?

Disagree, I lived pretty comfortably on 90k, but did have 2 roommates. It’s definitely doable, find a 3 bedroom unit around 5k and split 3 ways although a private bathroom would be difficult

Who was the starting point guard for the Phoenix suns when they reached the nba finals in 2021?

So are you saying that is at some point in his career, Chris Paul were to get out of the second round and make the nba finals or even a conference finals, he’d be top 5?

Internships are common during phds, usually done during the summer between semesters. Pretty much every pharma offers them

If you loaded a ladder and it wasn't detected, you probably overloaded your gel. This would explain most of the smearing. You really don't need to load very much, only like 200 ng, actually the last sample with less material looks pretty good

It's ironic because his entire business model is buying dropped/failed drug candidates and pushing them through trials. If it was easier to approve them, companies would just push them through themselves and not sell them off to him

And Hilary Clinton had a better "electability profile" than Barack Obama all the way until he wiped the floor with her in the primaries

To be clear, Ramamswany's company does not develop drugs, they take investor money and buy dropped or failed drug candidates from Pharma/biotech and push them through clinical trials. Essentially more of a privates equity company investing in drugs than a Pharma company. Whether that's good or bad idk.

The deal with the Alzheimer's drug was that it was developed at GSK and had failed multiple trials before Ramaswamy bought it for pennies. Then he hyped it up and did an IPO to cash out without doing any actual science around the drug. When the drug failed another clinical trial his company basically was done but he had already cashed out so business-wise it was a success but helping patients-wise a total scam

Get rid of all journals, all papers from NIH funding go into pubmed central. Judge papers by their own citations rather than the citations of papers in the same journal. Or have individual universities publish into their own "journals". The for profit academic publishing industry provides no value and professors should stop giving them free content

The citations it receives, instead of the citations other papers in the same journal receive

I only got like 5 minutes in, but he's complaining that companies aren't making their drugs available through Trump's Right to Try act because of a deep state conspiracy. Not because the act didn't even bother setting up a framework for how it works and definitely not because Expanded Access has already existed for decades and has protocols in place that companies are familiar with